Jesmonite is a versatile material and is used in several ways. It is typically used for creating sculptures and other three-dimensional works, but can be used with other materials as a ground for painting. It can be used as a surface material in building and construction. It is considered an attractive alternative to other resin-based materials, such as polyester and fiberglass. It can be used for casting and laminating.

Besides its popularity in sculpture, jesmonite is popular in other areas where casting and molding are common, such as architectural stone and plasterwork that has a requirement to be very lightweight.